ANTI-Growth Hormone

Somatostatin inhibits secretion of growth hormone from the pituitary gland . All known production for growth hormone secretion are suppressed by somatostatin administration. Additionally, animals treated with a somatostatin inhibitor show elevated blood concentrations of growth hormone, as do animals that are genetically engineered to disrupt their somatostatin gene.

Ultimately, growth hormone secretion is controlled by the interaction of somatostatin and growth hormone releasing hormone, both of which are secreted by hypothalamus

Effects on the Nervous System

Injection of somatostatin into the brain of rodents leads to such things as increased arousal and decreased sleep, and impairment of some motor responses.